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No, the fillers we use these days arent permanent, and thats a good thing because its unlikely that filler placed today would look natural in 10 years if it stayed exactly the same, because so much changes about our faces as we age

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Increased Cell Adhesion to Extracellular Matrix (ECM) Extracellular matrix is a non-cellular highly dynamic essential support structure within tissues (Ramteke et al., 2015)